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Martin Fugate and Elizabeth Smith who had married and settled near Hazard Kentucky around 1820 were both carriers of the recessive methemoglobinemia met-H geneAs a result four of their seven children exhibited blue skin and continued progenation within the very limited local gene pool ensured that many descendants of the Fugates were born with met-H. Plural ees Es or Es.

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It is the most commonly used letter in many languages including Czech Danish Dutch English French German Hungarian Latin Latvian Norwegian Spanish and Swedish.

. E or e is the fifth letter and the second vowel letter in the modern English alphabet and the ISO basic Latin alphabetIts name in English is e pronounced ˈ iː.

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